各学部の研究活動
がん治療学部発表論文・特許

原著論文

  1. Mitsuhashi K, Nosho K, Sukawa Y, Matsunaga Y, Ito M, Kurihara H, Kanno S, Igarashi H, Naito T, Adachi Y, Tachibana M, Tanuma T, Maguchi H, Shinohara T, Hasegawa T, Imamura M, Kimura Y, Hirata K, Maruyama R, Suzuki H, Imai K, Yamamoto H, Shinomura Y. Association of Fusobacterium species in pancreatic cancer tissues with molecular features and prognosis. Oncotarget, in press, 2015.
  2. Yamamoto H and Imai K. Microsatellite instability. Arch Toxicol, in press, 2015.
  3. Nosho K, Igarashi H, Ito M, Mitsuhashi K, Kurihara H, Kanno S, Yoshii S, Mikami M, Takahashi H, Kusumi T, Hosokawa M, Sukawa Y, Adachi Y, Hasegawa T, Okita K, Hirata K, Maruyama R, Suzuki H, Imai K, Yamamoto H, Shinomura Y. Clinicopathological and molecular characteristics of serrated lesions in Japanese elderly patients. Digestion, 91(1):57-63, doi: 10.1159/000368820, 2015.
  4. Yamamoto M, Takahashi H, Shimizu Y, Yajima H, Suzuki C, Naishiro Y, Imai K, Shinomura Y. Seasonal allergies and serial changes of serum levels of IgG4 in cases treated with maintenance therapy for IgG4-related disease. Modern Rheumatology, 13:1-2, doi: 10.3109/14397595.2014.995893, 2015.
  5. Yamamoto M, Nojima M, Takahashi H, Yokoyama Y, Ishigami K, Yajima H, Shimizu Y, Tabeya T, Matsui M, Suzuki C, Naishiro Y, Takano KI, Himi T, Imai K, Shinomura Y. Identification of relapse predictors in IgG4-related disease using multivariate analysis of clinical data at the first visit and initial treatment. Rheumatology, 54(1):45-9, doi: 10.1093/rheumatology/keu228, 2015.
  6. Nasuno M, Arimura Y, Nagaishi K, Isshiki H, Onodera K, Nakagaki S, Watanabe S, Idogawa M, Yamashita K, Naishiro Y, Adachi Y, Suzuki H, Fujimiya M, Imai K, Shinomura Y. Mesenchymal stem cells cancel azoxymethane-induced tumor initiation. STEM CELLS 32(4):913-25, doi: 10.1002/stem.1594, 2014.
  7. Yasui H, Tsurita G, Imai K. DNA synthesis inhibitors for the treatment of gastrointestinal cancer. Expert Opinion Pharmacother. 15(16):2361-72, doi:10.1517/14656566.2014.958074, 2014.
  8. Yasui H, Ishida T, Imai K. The role of DNA methylation in the genetics and epigenetics of multiple myeloma. In: Steve Holt, editors. Multiple myeloma: risk factors, diagnosis and treatments. :Series: Cancer Etiology, Diagnosis and Treatments. Hauppauge NY: Nova Science Publishers. 147-156. ISBN: 978-1-63321-514-6. 2014;
  9. Naito T, Nosho K, Ito M, Igarashi H, Mitsuhashi K, Yoshii S, Aoki H, Nomura M, Sukawa Y, Yamamoto E, Adachi Y, Takahashi H, Hosokawa M, Fujita M, Takenouchi T, Maruyama R, Suzuki H, Baba Y, Imai K, Yamamoto H, Ogino S, Shinomura Y. IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions. World J Gastroenterol. 20(29): 10050-61, doi:10.3748/wjg.v20.i29.10050, 2014.
  10. Yamamoto M, Yajima H, Takahashi H, Yokoyama Y, Ishigami K, Shimizu Y, Tabeya T, Suzuki C, Naishiro Y, Takano K, Yamashita K, Hashimoto M, Keira Y, Honda S, Abe T, Suzuki Y, Mukai M, Himi T, Hasegawa T, Imai K, Shinomura Y. Everyday clinical practice in IgG4-related dacryoadenitis and/or sialadentist: Result from the SMART database. Modern Rheumatol. 27:1-6, [Epub ahead of print] doi:10.3109/14397595.2014.950036, 2014.
  11. Harada T, Yamamoto E, Yamano H, Nojima M, Maruyama R, Kumegawa K, Ashida M, Yoshikawa K, Kimura T, Harada E, Takagi R, Tanaka Y, Aoki H, Nishizono M, Nakaoka M, Tuyada A, Niinuma T, Kai M, Shimoda K, Shinomura Y, Sugai T, Imai K, Suzuki H. Analysis of DNA methylation in bowel lavage fluid for detection of colorectal cancer. Cancer Prevention Research (Philadelphia, Pa.), 7(10):1002-10, doi:10.1158/1940-6207.CAPR-14-0162, 2014.
  12. Igarashi H, Kurihara H, Mitsuhashi K, Ito M, Okuda H, Kanno S, Naito T, Yoshii S, Takahashi H, Kusumi T, Hasegawa T, Sukawa Y, Adachi Y, Okita K, Hirata K, Imamura Y, Baba Y, Imai K, Suzuki H, Yamamoto H, Nosho K, Shinomura Y. Association of microRNA-31-5p with clinical efficacy of anti-EGFR therapy in patients with metastatic colorectal cancer. Ann. Surgical Oncol. [Epub ahead of print], 2014.
  13. Kagami H, Agata H, Inoue M, Asahina I, Tojo A, Yamashita N, Imai K. The Use of Bone Marrow Stromal Cells (Bone Marrow-Derived Multipotent Mesenchymal Stromal Cells) for Alveolar Bone Tissue Engineering: Basic Science to Clinical Translation. Tissue Engineering Part B: Reviews. 20(3): 229-232, doi:10.1089/ten.TEB.2013.0578, 2014.
  14. Ito M, Mitsuhashi K, Igarashi H, Nosho K, Naito T, Yoshii S, Takahashi H, Fujita M, Sukawa Y, Yamamoto E, Takahashi T, Adachi Y, Nojima M, Sasaki Y, Tokino T, Baba Y, Maruyama R, Suzuki H, Imai K, Yamamoto H, Shinomura Y. MicroRNA-31 expression in relation to BRAF mutation, CpG island methylation and colorectal continuum in serrated lesions. Int J Cancer. 135(11):2507-15, doi: 10.1002/ijc.28920, 2014.
  15. Yamamoto M, Shimizu Y, Takahashi H, Yajima H, Yokoyama Y, Ishigami K, Tabeya T, Suzuki C, Matsui M, Naishiro Y, Imai K, Shinomura Y. CCAAT/enhancer binding protein α (C/EBPα)+ M2 macrophages contribute to fibrosis in IgG4-related disease? Mod Rheumatol, 2:1-3, [Epub ahead of print], 2014.
  16. Adachi Y, Ohashi H, Imsumran A, Yamamoto H, Matsunaga Y, Taniguchi H, Nosho K, Suzuki H, Sasaki Y, Arimura Y, Carbone DP, Imai K, Shinomura Y. The effect of IGF-I receptor blockade for human esophageal squamous cell carcinoma and adenocarcinoma. Tumor Biol 35(2): 973-85, doi10.1007/s13277-013-1131-2, 2014.
  17. Fujii T, Horiguchi K, Sunaga H, Moriwaki Y, Misawa H, Kasahara T, Tsuji S, Kawashima K: SLURP-1, an endogenous alpha7 nicotinic acetylcholine receptor allosteric ligand, is expressed in CD205+ dendritic cells in human tonsils and potentiates lymphocytic cholinergic activity. J Neuroimmunol, 267:43-49, 2014
  18. Tsuji S, Yamashita M, Kageyama T, Ohtsu T, Suzuki K, Kato S, Akitomi J, Furuichi M, Waga I: Hishot display—a new combinatorial display for obtaining target-recognizing peptides. PLoS ONE, 8:e83108, 2013
  19. Noguchi A, Kikuchi K, Ohtsu T, Yoshiwara M, Nakamura Y, Miyagi Y, Zheng H, Takano Y: Pulmonary tumors associated with the JC virus T-antigen in a transgenic mouse model. Oncol Rep. 30:2603-2608, 2013
  20. Washimi K, Yokose T, Yamashita M, Kageyama T, Suzuki K, Yoshihara M, Miyagi Y, Hayashi H, Tsuji S. Specific expression of human intelectin-1 in malignant pleural mesothelioma and gastrointestinal goblet cells. PLoS One 7:e39889, 2012.
  21. Matsumoto T, Ryuge S, Kobayashi M, Kageyama T, Hattori M, Goshima N, Jiang S-X, Saegusa M, Iyoda A, Satoh Y, Masuda N, Sato Y. Anti HuC and HuD autoantibodies are differential sero-diagnostic markers for small cell carcinoma from large cell neuroendocrine carcinoma of the lung. Int J Oncol 40:1957-62, 2012.
  22. Xu S, Butkevich AN, Yamada R, Zhou Y, Debnath B, Duncan R, Zandi E, Petasis NA, Neamati N. Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment. Proc Natl Acad Sci U S A. 109(40):163 (2012)
  23. Yamada R, Cao X, Butkevich AN, Millard M, Odde S, Mordwinkin N, Gundla R, Zandi E, Louie SG, Petasis NA, Neamati N. Discovery and preclinical evaluation of a novel class of cytotoxic propynoic acid carbamoyl methyl amides (PACMAs). J Med Chem 54(8):2902-14, 2011.
  24. Kageyama T, Nagashio R, Ryuge S, Matsumoto T, Iyoda A, Satoh Y, Masuda N, Jiang SX, Saegusa M, Sato Y. HADHA is a potential predictor of the response to platinum-based chemotherapy. Asian Pacific J Cancer Prev 12:3457-3463, 2011.
  25. Nagashio R, Sato Y, Matsumoto T, Kageyama T, Hattori M, Iyoda A, Satoh Y, Ryuge S, Masuda N, Jiang S-X, Saegusa M. The balance between the expressions of hASH1 and HES1 differes between large cell neuroendocrine carcinoma and small cell carcinoma of the lung. Lung Cancer 74:405-410, 2011.
  26. Morimura S, Suzuki K, Takahashi K. Nonmuscle myosin IIA is required for lamellipodia formation through binding to WAVE2 and phosphatidylinositol 3,4,5-triphosphate. Biochem Biophys Res Commun 404:834-840, 2011.
  27. 大津敬. DNAはタンパク質をこえるか?. パリティ 26:22-25, 2011.
  28. 林, 金, 寺薗, 服部, 安田, 大津, 宮城, 荒尾, 西尾. CTC計測装置技術の現状と次世代CTC装置技術の展望. Cytometry Research 21:1-6, 2011.
  29. Tsuji S, Tsuura Y, Morohoshi T, Shinohara T, Oshita F, Yamada K, Kameda Y, Ohtsu T, Nakamura Y, Miyagi Y. Secretion of intelectin-1 from malignant pleural mesothelioma into pleural effusion. British Journal of Cancer 103:517-523, 2010.
  30. Yamada R, Kostova MB, Anchoori RK, Xu S, Neamati N, Khan SR. Biological evaluation of paclitaxel-peptide conjugates as a model for MMP2-targeted drug delivery. Cancer Biol Ther 9(3):192-203, 2010
  31. Tsuji S, Hirabayashi N, Kato S, Akitomi J, Egashira H, Tanaka T, Waga I, Ohtsu T. Effective isolation of RNA aptamer through suppression of PCR bias. Biochemical and Biophysical Research Communications 386:223-226, 2009.
  32. Tsuji S, Tanaka T, Hirabayashi N, Kato S, Akitomi J, Egashira H, Waga I, Ohtsu T. RNA aptamer binding to polyhistidine-tag. Biochemical and Biophysical Research Communications 386:227-231, 2009.
  33. Werner T, H?rmannsperger G, Schumann K, H?lzlwimmer G, Tsuji S, Haller D. Intestinal Epithelial Cell Proteome from wild type and TNFニARE/WT mice: effect of iron on the development of chronic ileitis. Journal of Proteome Research 8:3252-3264, 2009.
  34. Tsuji S, Yamashita M, Hoffman DR, Nishiyama A, Shinohara T, Ohtsu T, and Shibata Y. Capture of heat-killed Mycobacterium bovis bacillus Calmette-Gu?rin by intelectin-1 deposited on cell surfaces. Glycobiology 19:518-526, 2009.

特許

  1. 谷口博昭、今井浩三、片岡一則、西山伸宏、宮田完二郎、前田芳周 「転写因子PRDM14のがん幹細 胞診断マーカーへの応用とがん幹細胞を標的とした治療法の開発」発明等の届出書提日:2013年7月10日(出願番号2013-145044)
  2. 安田, 寺薗, 金, 林, 服部, 宮城, 大津.「細胞分析装置」(特開2011-257241)
  3. 平林 直己, 辻 祥太郎, 秋冨 穣, 加藤 信太郎, 和賀 巌, 大津 敬. c-Met結合核酸分子およびその用途. 特許出願中(特願2010-167342)
  4. 辻 祥太郎, 秋冨 穣, 加藤 信太郎, 和賀 巌, 大津 敬. ペプチドを認識するアプタマー. 国際特許出願中(PCT/JP2010/058221)
  5. 竹中 洋美, 秋富 穣, 加藤 信太郎, 辻 祥太郎, 大津 敬, 和賀 巌. HMGB1特異的アプタマーおよびその用途. 特許出願中(特願2009-167622)5) 大津 敬, 辻 祥太郎. ペプチドタグを認識するアプタマー. 特許出願中(特願2009-119269)

各学部の研究活動